期刊简介
本杂志是由中华人民共和国卫生部主管，同济医科大学附属协和医院主办，国内外公开发行的学术性期刊，被国家科技部列为“中国科技论文统计源期刊”，被中国科学文献计量评价研究中心认定为《中国科学引文数据库》来源期刊。设有专家笔谈、临床研究、实验研究、研究报告、综述、进修苑、学术争鸣、经验介绍及病例报告等栏目。
往期目录
-
1999
-
2000
-
2001
-
2002
-
2003
-
2004
-
2005
-
2006
-
2007
-
2008
-
2009
-
2010
-
2011
-
2012
-
2013
-
2014
-
2015
-
2016
-
2017
-
2018
首页>临床血液学杂志
- 杂志名称：临床血液学杂志
- 主管单位：中华人民共和国教育部
- 主办单位：华中科技大学同济医学院附属协和医院 北京大学医学院血研所
- 国际刊号：1004-2806
- 国内刊号：42-1284/R
- 出版周期：双月刊
期刊荣誉：中国核心期刊数据库收录期刊期刊收录：国家图书馆馆藏, 万方收录(中), 上海图书馆馆藏, CA 化学文摘(美), 统计源核心期刊(中国科技论文核心期刊), 知网收录(中), 维普收录(中)
成人急性淋巴细胞白血病中枢神经系统白血病的诊断和处理
何静；严晗；胡豫；刘新月；胡俊斌
关键词：白血病, 淋巴细胞, 急性, 中枢神经系统白血病, 诊断, 治疗
摘要：The cure rates in adults with acute lymphoblastic leukemia (ALL) remain at only 30％ to 40％ and that of Ph-positive ALL is less than 20 ％.Recurrence is a main obstacle to improve prognosis.Central nervous system (CNS) involvement at initial presentation decreases the overall survival.Without prophylaxis,the CNS recurrence reaches 30％ of adult ALL in complete remission (CR) and the outcome is poor.But the diagnosis and treatment of central nervous system leukemia (CNSL) is easy to be ignored and this subject has not been addressed as thoroughly.In this article,we present a 49 years old female with Ph-positive ALL.She had CNS recurrence after achieved CR by treatment with imatinib plus chemotherapy without enough CNS prophylaxis.Then she attained CR again by intrathecal methotrexate and oral dasatinib plus low intense systemic chemotherapy.The performance,diagnosis and risk factors of CNSL,methods of CNSL prophylaxis and treatment in adult patients with ALL especially Ph-positive cases are discussed.
友情链接