期刊简介
本杂志是由中华人民共和国卫生部主管,同济医科大学附属协和医院主办,国内外公开发行的学术性期刊,被国家科技部列为“中国科技论文统计源期刊”,被中国科学文献计量评价研究中心认定为《中国科学引文数据库》来源期刊。设有专家笔谈、临床研究、实验研究、研究报告、综述、进修苑、学术争鸣、经验介绍及病例报告等栏目。
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首页>临床血液学杂志

- 杂志名称:临床血液学杂志
- 主管单位:中华人民共和国教育部
- 主办单位:华中科技大学同济医学院附属协和医院 北京大学医学院血研所
- 国际刊号:1004-2806
- 国内刊号:42-1284/R
- 出版周期:双月刊
期刊荣誉:中国核心期刊数据库收录期刊期刊收录:国家图书馆馆藏, 万方收录(中), 上海图书馆馆藏, CA 化学文摘(美), 统计源核心期刊(中国科技论文核心期刊), 知网收录(中), 维普收录(中)
嗜碱性粒细胞增多的急性白血病1例报告并文献复习
彭楠;魏辉;周春林;王迎;刘凯奇;魏述宁;张广吉;邱少伟;秘营昌;王建祥
关键词:白血病, 急性, 嗜碱性粒细胞增多
摘要:To explore the differential diagnosis of acute leukemia with basophilia,we analyzed clinical features,morphology,immunophenotyping,cytogenetics and molecular genetics from one case and reviewed relevant literatures.The patient had fatigue,fever,cough and splenomegaly.Mature basophils increased in the peripheral blood,bone marrow samples and electron microscopic evaluation.Bone marrow aspiration showed 54 % mature basophils.The blasts fulfilled the criteria of acute myeloid leukemia.Immunophenotyping revealed CD34+,HLA-DR+,CD117+,CD33+,CD13+,CD123+,CD38+.Fluorescence in situ hybridization found loss of P53/CEP17 and positive for BCR/ABL.The BCR/ABL p230 transcript determined by RT-PCR was 99.56%.Acute leukemia with basophilia is not common.Chronic myelogenous leukemia in blast crisis,acute myeloid leukemia with t(9;22)(q34;q11) or other abnormalities and basophilic leukemia can have basophilia,hence the differential diagnosis is useful in making a clear diagnosis and choosing an appropriate treatment.
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